- Endol, an electric catfish who fought Bomberman on Planet Bomber.
- Baruda, a giant bird, Endol's younger brother and first pupil, who fought Bomberman on Primus Star.
- Bolban, a sphinx-like lion who turned Pibot to stone and fought Bomberman on Kanatia Star.
- Natia, a humanoid cat who fought Bomberman with her pet, Cronus, on Mazone Star.
All four of them, along with Cronus, were killed by Bomberman but were restored to life by Bagular after he was revived by Nitros. Bomberman fought all of them again on Garaden Star and destroyed them all again, this time for good. In the process, Nitros was freed from Garaden's control.
- All of the members of the Big Four are based off of animals.